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Pure Wellness Medical Supplements

PURE Wellness Inflamm Support

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$60.25 USD
Regular price
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$60.25 USD
  • Description
  • Serving Size: 3 capsules - 240 capsules per bottle   80-day supply

    Directions: As a dietary supplement, take three (3) capsules with 8-12 fl oz of water daily.

    BENEFITS: Ingredients have been shown to reduce inflammatory markers, possess antioxidant properties, and help to decrease cellular damage. This special combination is formulated to reduce inflammation locally and throughout the entire body.


    QUERCETIN: Plant pigment and long-lasting anti-inflammatory that contains strong anti-inflammatory capacities across multiple kinds of cells.

    BOSWELLIA SERRATA: Strong anti-inflammatory agent used to treat various chronic inflammatory diseases.

    TURMERIC(CURCUMIN): Powerful anti-inflammatories and antioxidants that aid in reducing and preventing systemic and localized inflammation.

    ALPHA-LIPOIC ACID: Antioxidant nutrient that assists in nutrient breakdown and has been found to contain strong anti-inflammatory properties.

    RESVERATROL: Found to increase metabolic rate and inhibit triggers of inflammation throughout the body.

    GREEN TEA: Contains antioxidants and EFCF,which have been found to naturally reduce inflammation.

    BROMELAIN: Encourages the body to produce vital substances to support a healthy immune system.

    ZINC: Crucial for normal development and function of cells. 

  • Clinical evidence
  • Two specific studies showed Quercetin was reported as a long-lasting anti-inflammatory substance that possesses strong anti-inflammatory capacities (1,2). Several studies shoe quercetin to possess anti-inflammatory potential that can be expressed on different cell types, both in animal and human models (3,4,5,6,7,8,9,10,11). Quercetin possess both mast cell stabilizing and gastrointestinal cytoprotective activity (12). It can also play a modulating, biphasic and regulatory action on inflammation and immunity (11). Additionally, quercetin has an immunosuppressive effect on dendritic cells function (13). Boswellia serrata has been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseases. The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids (14). In Several in-vitro studies and animal models show that boswellic acids were found to inhibit the synthesis of pro-inflammatory enzyme, 5-lipoxygenase [5-LO] including 5-hydroxyeicosatetraenoic acid [5-HETE] and leukotriene B4 [LTB-4], which cause bronchoconstriction, chemotaxis, and increased vascular permeability (15-20). Boswellic acids seem to be specific inhibitor of 5-LO (21). 5-LO generates inflammatory leukotrienes, which cause inflammation by promoting free radical damage, calcium dislocation, cell-adhesion and migration of inflammation-producing cells to the inflamed body area. Boswellic acids have been shown to significantly reduce glycosaminoglycan degradation (22–25). Clinical trials of gum-resin of Boswellia alone have shown to improve symptoms in patients with osteoarthritis, and rheumatoid arthritis (26,27). A clinical trial conducted by Raychaudhuri and co-workers in India has shown that the extract of the plant, Boswellia serrata, can reduce pain and improve knee-joint functions, in some cases providing relief even within seven days. Raychaudhuri and her colleagues described their study as the first to evaluate the efficacy of the extract enriched with a form of boswellic acid on osteoarthritis (28). Very recently, Pawar et al. in 2011 have reported a simple, rapid, accurate, reproducible, selective and economic HPTLC method for routine quality control analysis as also quantitative determination of β-boswellic acid from Boswellia serrata Roxb. (exudate) and its formulations (29). Turmeric is the spice that gives curry its yellow color. It has been used in India for thousands of years as both a spice and medicinal herb. These compounds are called curcuminoids. Curcumin is the main active ingredient in turmeric. It has powerful anti-inflammatory effects and is an extraordinarily strong antioxidant (30,31). Extensive research has demonstrated the mechanism by which persistent oxidative stress can lead to chronic inflammation, which in turn could cause many chronic diseases including cardiovascular diseases, neurological diseases, pulmonary diseases, diabetes, and cancers (32). Alpha-lipoic acid or ALA is a naturally occurring compound that is made in the body. Increased pro-inflammatory markers and oxidative stress occurs in adipose tissues are the two factors that may play a key role in the incidence of metabolic-related comorbidities among patients with metabolic disorders (33). Increased chronic inflammation is associated with increased risk of metabolic disorders, including type 2 diabetes mellitus (T2DM) (34) and arteriosclerosis, endothelial dysfunction, vascular calcification, increased activity of metalloproteinases, oxidative damage, and degradation of collagen (35-37). Increased levels of CRP are associated with increased risk of CVD and diabetes (38,39). In addition to CRP, other inflammatory biomarkers such as IL-6 and TNF-α may be correlated with the development of CVD in diabetic patients (40). The results of current meta-analysis showed that ALA supplementation significantly decreased CRP, IL-6, and TNF-α levels in patients with MetS and related disorders. In a large meta-analysis of eighteen different studies showed that ALA supplementation significantly decreased CRP, IL-6, and TNF-α levels in patients with MetS and related disorders (41). Resveratrol is produced by plants as a phytoalexin in response to a stressful stimulus, or to a microbial or fungal infection, providing the plant resistance (42). Chronic, low-grade inflammation can underlie the development of several non-communicable diseases, including cancer, and neurodegenerative, respiratory, metabolic, and cardiovascular diseases. Accumulating data strongly suggest that phytochemicals can interact with multiple targets, and alter the dysregulated inflammatory pathways and mediators, indicating treatment of the inflammatory processes underlying chronic diseases (43). RSV treatment also leads to increases in the metabolic rate and mitochondrial number, which might be correlated with increases in peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) activity and expression, which control mitochondrial biogenesis in the liver and muscle (44-47). Green tea has been shown to have beneficial effects against a variety of diseases such as cancer, obesity, diabetes, cardiovascular disease, and neurodegenerative diseases. Green tea and its major component, epigallocatechin-3-gallate (EGCG) have been demonstrated to have anti-inflammatory effects (48). Green tea and EGCG have multiple targets and act in a pleiotropic manner, it is essential to consider their usage to improve the quality of life in patients with inflammatory disease. Green tea and EGCG have beneficial health effects and no severe adverse effects (48). Bromelain is a mixture of different thiol endopeptidases and other, and several protease inhibitors (49). In vitro and in vivo studies demonstrate that bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities (49). Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics (49). It also relieves osteoarthritis, diarrhea, and various cardiovascular disorders. Bromelain also possesses some anti-cancerous activities and promotes apoptotic cell death (49). Shankar et al. in one study showed Zinc to be crucial for normal development and function of cells mediating nonspecific immunity such as neutrophils and natural killer cells (50). They also found Zinc deficiency to affect development of acquired immunity by preventing both the outgrowth and certain functions of T lymphocytes such as activation, Th1 cytokine production, and B lymphocyte help. The study also showed B lymphocyte development and antibody production, particularly immunoglobulin G, to be compromised with Zinc deficiency (50). They showed how the macrophage, a pivotal cell in many immunologic functions, is adversely affected by zinc deficiency, which can dysregulate intracellular killing, cytokine production, and phagocytosis (50). Shankar et al. explained zinc to be a key immunologic mediator that is rooted in the myriad roles for zinc in basic cellular functions such as DNA replication, RNA transcription, cell division, and cell activation (50). Zinc also functions as an antioxidant and can stabilize membranes (50).

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